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ALEXANDER USYATINSKYXXXXXX
YYYYYYYYyyyyy x. yyyyyy, Ph.D.
Phone: (xxx-xxx-xxxx518) 283 3506 6 Aaverlord Blvd.
Cell: (xxx-xxx-xxxx518) 331 6553
XxxxxxXxxxxxXxxxxxTroyXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX, NYxxxxxxxxxxxxxxxxxx0000 xxxxxx
xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx
, xxxx , xxxxx 00000 12180
e-mail: xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxausyatin@nyabc@xyz.comabc@xyz.comabc@xyz.comcap.rr.com
Alexander
Usyatinsky, Ph.D.XXXXXX YYYYYYYYyyyyy x. yyyyyy
6 Aavelord BlvdXxxxxxXxxxxxXxxxxx
Troy, NYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 12180xxxxxxxxxxxxxxxxxx0000
xxxxxx xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx , xxxx , xxxxx 000000000
xxxxxx xxxx , xxxx , xxxxx 00000
518-283-3506 xxx-xxx-xxxx
xxx-xxx-xxxx
518-331-6553 xxx-xxx-xxxx
xxx-xxx-xxxx
ausyatin@nyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxcap.rr.comabc@xyz.comabc@xyz.comabc@xyz.com
Country of Citizenship: United States
SSN: xxx-xx-xxxx
Job Title:
Patent Examiner - Chemistry Department: Department Of Commerce
Agencxxxxxxy: Patent and Trademark Office
Job Announcxxxxxxement Number: LD376528; 2. Job Title: Patent Examiner - Chemical Engineering
Department: Department of Commerce
Agencxxxxxxy: Patent and Trademark Office
Job Announcxxxxxxement Number: LD37350xxxxxx0
Core Competencxxxxxxies
Patent Examination;
Chemistry; Chemical Engineering; Medicinal Chemistry; Synthetic Organic Chemistry; Organometallic
Chemistry; Scientific Research; Scientific Data
Analysis; Biological Data Evaluation; Scientific
Information Editing; Scientific Writing; Compound Isolation; Multi-Step
Organic Synthesis; Microwave Assisted Solution Free Synthesis; Main Group
Metals and Boronorganic Compounds Synthesis; Drug Discovery; Product
Development; R&D; Project Management; Laboratory
Management; Synthesis Methodology; Active
Structure Development; SAR Studies; Presentations &
Discussions; Teaching; Team Leadership; Training/Mentorship;
Client Communications; Customer
Relations
SUMMARY OF QUALIFICATIONS:
Extensive experiexxxxxxnce in medicinal, synthetic
organic and organometallic chemistry
Specializing in multistep organic synthesis, microwave assisted solution
free synthesis, synthesis of main group metals- and boronorganic compounds
Experiexxxxxxnce in scientific
information analysis and editorial work
Foreign languages proficiexxxxxxncy: Russian,
Ukrainian (fluent), Polish, Serbo-Croatian.
.
EMPLOYMENTEmployment
BackgroundEMPLOYMENT:
02/2010-present
GE Global Research Center/ Yoh (Contractor)
Niskayuna, New YorkXxxxxxXxxxxxXxxxxxXxxxxxXxxxxx US
Hours per Week: 40
Salary: 40/hour USD
Supervisor: Dr. Grigorii Soloveichik (518) 387-7906 xxx-xxx-xxxx
; May contact
2010-present
Chemist-Temporary
Proficiently devise synthesis of ligands and organometallic catalysts supporting fuel cells-based energy devices for Energy Frontier Research Center.
Devised synthesis of ligands and
organometallic catalysts for fuel cells based energy devices
08/2001- 08/2009
Albanyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Molecular Research Incxxxxxx. (AMRI)
, Albaxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxny, XxxxxxXxxxxxXxxxxxXxxxxxXxxxxxNew York
Senior Research Scientist Department
of Medicinal Chemistry/Drug Discovery
Research
and Development
Albanyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx, New YorkXxxxxxXxxxxxXxxxxxXxxxxxXxxxxx US
Hours per Week: 40
Salary: 78,800/annual USD
Supervisor: Mathew Surman (518) 464-0279 xxx-xxx-xxxx
; May Contact
Senior Research Scientist
Page 1 of 4
Alexander Usyatinsky, Ph.D.XXXXXX YYYYYYYYyyyyy x. yyyyyy Page 2 of 4
Retained after EnzyMed buyout and merger with AMRI to oversee client engagements as well as internal R&D projects; consistently ensured achievement of critical customer specifications and deadlines through strategic coordination, scheduling and management of multi-task workflow. Conferred with clients throughout projects and delivered routine progress reports. Successfully collaborated with major pharmaceutical firms in developing and synthesizing
Developed and synthesized potential drug
candidates, playing a key
role in generating profits for both client and AMRI. Effectively
improved on customer-proposed compounds to achieve targets in developing new
structures and synthesizing a series of active drug
candidates; optimal candidate currently in Stage I & II clinical trials
with another licensed by customers to Gilead Sciencxxxxxxes.
Targeting Cystic Fibrosis and Chronic Broncxxxxxxhitis treatments, e in
collaboration with major
pharmaceutical companies;
Elucidated synthesis and SAR of novel
substituted pyrazinoylguanidines
as a sodium channel blockers. Developed
project from 3-month customer contract supported by 1 chemist to 5-year
contract employing 8 full-time staff.
Efficiently c for the treatment of
cystic fibrosis and chronic broxxxxxxnchitis.
Conducted synthesis and investigated of structure/-activity
relationship of new 5-HT3 antagonists/partial agonists as potential drugs for applications in
against IBS-D
and IBS-C; developed new compound with
strong potential for conditions and as a result, identified drug with
applications in preventing emesis in cancxxxxxxer patients
undergoing chemotherapy. .
DDeveloped
synthesis and investigated
SAR
of non-steroidal anti-inflammatory agents.
Designed new, scalable synthesis methodology for
synthesized active metabolite. Created pharmacologically-acceptable form
of product by establishing an effective method.
In support of major obesity project, derived new synthetic method for
preparation of a backup candidate that could not be synthesized using the
primary method due to structural differencxxxxxxes.
01/1995-08/2000
EnzyMed
Incxxxxxx.
, Iowa
City,
Iowa US
Hours per Week: 40
Salary: 53K/annual USD
Supervisor: Dr. Yuri Khmelnitsky (518) 512-2890 xxx-xxx-xxxx
; May Contact
Senior Scientist,
Scientist ,Scientist, Industrial
Post-Doctoral Fellow
Strategically applied Applied microwave
activation to heterocyclic condensation reactions in combinatorial
format. D
Developed methodology a method for
scavenging excess of acyl donors with solid phase reagents.
Synthesized Conducted synthesis of Paclitaxel
(Taxol) derivatives with incxxxxxxreased
water solubility.
08/1976-04/1994
Russian Academy of Sciexxxxxxnces
A.N. Senior Research
Associate Nesmeyanov Institute of Organo-Element Compounds,
Research
Associate
Moscow,
Russia
Hours per Week: 40
Salary: 300/month RUB
Supervisor: Prof. Vladimir Bregadze 7-495-934-3067; May Contact
Senior Research Associate
Developed novel mercury and
thallium derivatives of carboranes/metallocarboranes as well as clearly defined nd determined their stereo
and regiochemistry. Resourcefully created enhancxxxxxxed
Created an improved thallation methodology towardss the synthesis
of organoboron compounds.
Designed efficient method for
separating veloped method to
separate a mixture of C60of C60 and C70
fullerenes. In support of cancxxxxxxer therapy,
sSynthesized
novel boron-containing compounds for neutron capture. Effectively e caxxxxxxncer therapy.developed
Developed mechano-chemical methods focused on isolatingr the isolation
of thallium from waste.
Alexander Usyatinsky, Ph.D.XXXXXX
YYYYYYYYyyyyy x. yyyyyy
Page 3 of 4
Concxxxxxxurrently
contributed subject matter expertise and dynamic communication skills toward
delivering student classroom instruction and facilitating lab supervision
in General Organic Chemistry Taught general
organic chemistry and supervised laboratory classes for students at of G.I. Plekhanov Russian Economic Academy.
;
Developed novel mercury and thallium derivatives of
carboranes and metallocarboranes and studied their stereo- and regiochemistry
and crystal structure.
Developed method of separation of fullerenes C60 and C70 using column chromatography.
Elucidated methods of synthesis of novel boron-containing
compounds for
the
use in neutron capture
caxxxxxxncer therapy.
10/1982-05/1990
Vsesoyuznyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxi Institute Nauchno-Techniceskoi Informacii
Referativnyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxi Zhurnal Khimiya
Moscow, Russia
Hours per Week: 10
Salary: 30/month RUB
Supervisor: Alexander Ryabov (phone # N/A); May Contact
Document Analysis
Specialist (part time)
Expertly analyzed journal paper
and patent Analyzed scientific
information from journal papers and patents in
synthetic
organic chemistry,
coordination compound
chemistry and , chemical
kinetics.
11/ 1988-03/1993
Metaloorganicheskaya Khimiya
-
Editor (part time)
(Organometallic
Chemistry in USSR
Moscow, Russia
Hours per Week: 10
Salary: 10/week RUB
Supervisor: Prof. Vladimir
Bregadze 7-495-934-3067; May Contact)
Editor and Reviewer (part time)
Comprehensively rReviewed
and
proofread scientific
content of papers submitted for publication.
the submitted papers and performed proofreading.
Education
DUCATION:
1984 Nesmeyanov
Institute of Organo-Element Compounds
,Moscow, Russia
Degree:
Ph.D. in Chemistry.
Earned: 1984
GPA: N/A-currently under review
for US equivalencxxxxxxy ranking
TThesis: Carboraxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxnyl Carboranyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxl
derivatives of thallium (III)
1976 M.V. Lomonosov MoscowLomonosov Moscow State University
, Moscow, Russia
Degree: M.Sc.
in Chemistry
Earned: 1976
GPA: N/A-currently under review
for US equivalencxxxxxxy ranking
PatentsPATENTS:
1. P.R. Guzzo, M.D.Surman, M.D.Surman, Henderson
A.J, M.X. Jiang, M. Hadden, J. Grabowski, A.Usyatinsky,
1-Azinone)-substituted
pyridonindoles
US Patent application 20090xxxxxx27559xxxxxx
xxx-xxx-xxxx 0000 xxxxxx xxxx , xxxx , xxxxx 000000
2. Y.L. Khmelnitsky, C.L. Buddy, J.M. Arnold, J.O. Rich, S.S. Chen, A.Ya. Usyatinsky, D.S.Clark, J.S.Dordick, Two Step Enzymatic Acylation US Patent 6,261,813 B1 0.7, 17, 2001.
3. S.H. Chen, C.S. Galka, S.L.Hellman, J.L. Krstenantsky, M.L. Rodrigues, J. Xicheng , A. Ya. Usyatinsky, V. Vasudevan, M.J. Zweifel Pseudomycin amid and ester analogs PCT WO 01/05817 A1 0.1 25, 2001.
Alexander Usyatinsky, Ph.D.XXXXXX
YYYYYYYYyyyyy x. yyyyyy
Page 4 of 4
US Patent 6,261,813 B1 0.7, 17, 2001
PCT WO 01/05817 A1 0.1 25, 2001
Publications/PresentationsPUBLICATIONS
:
More than 40 papers
in International and Russian Journals as well as several presentations at
International Conferencxxxxxxes-full listing
available on request, with Most Recent incxxxxxxluding:
.
The most recent publications:
1. M. Bai, G. Carr, R.l J. DeOrazio T. D. Friedrich , S Dobritsa, Kevin Fitzpatrick ,
P. R. Guzzo , D. B. Kitchen , M.
A. Lyncxxxxxxh , D. Peace ,
M. Sajad, A. Usyatinsky, M. A. Wolf: 5-Funcxxxxxxtionalized
indazoles as glucocorticoid receptor agonists. , Bioorg.Med.Chem.Lett., 2010,
20, 3017-3020.
2. A J. Hirsh, B. F. Molino, J.
Zhang, N. Astakhova, W. B. Geiss, B. J. Sargent, B. D. Swenson, A. Usyatinsky, M. J. Wyle, R. C. Boucher, R.
T. Smith, A. Zamurus, and M. R. Johnson Design, Synthesis and Structure
Activity Relationship on Novel 2-substituted Pyrazinoylguanidine
Epothelia Sodium Channel Blockers: Drug for Cystic Fibrosis and Chronic Broncxxxxxxhitis. J.
Med. Chem, 2006, 49(14),
4098-4115.
3. A. Usyatinsky, N.A. Astakhova, Yu.L. Khmelnitsky Simple and Efficient Solid Support Scavenging of Excess Acyl Donors after Enzymatic Acylations in Organic Solvents , Biotechnology and Bioengineering, 2003, 82, 380-385.
4. A. Usyatinsky, Yu.L. Khmelnitsky Microwave assisted synthesis of substituted imidazoles on solid support under solvent free conditions , Tetrahedron Lett., 2000, 41, 5031-5034.
5. I.C. Cotterill, A. Usyatinsky, J.M. Arnold, D.S. Clark, J.S. Dordick, P.C. Michels, Yu.L. Khmelnitsky Microwave Assisted Combinatorial Chemistry. Synthesis of Substituted Pyridines Tetrahedron Lett. 1998, 39, 1117-1120.
6. V.V.Mozhaev, C.L.Budde, J.O.Rich, A. Usyatinsky, P.C.Michels, Yu.L.Khmelnitsky, D.S.Clark, J.S.Dordick Regioselective Enzymatic Acylation as a Tool for Producing Solution Phase Combinatorial Libraries , Tetrahedron, 1998, 54, 3971-3982.
7. Yu.L. Khmelnitsky, C. Budde, J.M. Arnold, A. Usyatinsky, D.S. Clark, J.S. Dordick
Synthesis of Water Soluble
Paclitaxel Derivatives by Enzymatic Acylation J.
Am. Chem. Soc.
1997, 119, 11554xxxxxx0000
xxxxxx xxxx , xxxx , xxxxx 00000-11555xxxxxx.
Languages
Multi-Lingual: English, Russian, Ukrainian, Polish, Serbo-Croatian
Professional Affiliations
Member, American Chemical Society
Member, Patroon Toastmasters Club
A J. Hirsh, B. F. Molino, J.
Zhang, N. Astakhova, W. Geiss, B. Sargent, B. Swenson, A. Ya. Usyatinsky, M. J. Wyle, R. C. Boucher, R.
T. Smith, A. Zamurus, and M. R. Johnson
Design, Synthesis and
Structure Activity Relationship on Novel 2-substituted Pyrazinoylguanidine Epothelia
Sodium Channel Blockers: Drug for Cystic Fibrosis and Chronic Broxxxxxxnchitis.
J.Med. Chem, 2006, 4098-4115
A.Ya. Usyatinsky, N.A. Astakhova, Yu.L. Khmelnitsky
Simple and Efficient Solid Support
Scavenging of Excess Acyl Donors after Enzymatic Acylations in Organic
Solvents
Biotech logy and
Bioengineering, 2003, 82, 380-385.
A.Ya. Usyatinsky, Yu.L. Khmelnitsky
Microwave assisted synthesis of
substituted imidazoles on solid support under solvent free conditions
Tetrahedron Lett., 2000, 41, 5031-5034
I.C.Cotterill, A.Ya. Usyatinsky, J.M. Arnold, D.S. Clark, J.S. Dordick, P.C. Michels, Yu.L. Khmelnitsky
Microwave Assisted Combinatorial
Chemistry. Synthesis of Substituted Pyridines
Tetrahedron Lett. 1998, 39, 1117-1120.
V.V.Mozhaev, C.L.Budde,
J.O.Rich, A.Ya. Usyatinsky, P.C.Michels, Yu.L.Khmelnitsky,
D.S.Clark, J.S.Dordick
Regioselective Enzymatic
Acylation as a Tool for Producing Solution Phase Combinatorial Libraries Tetrahedron, 1998, 54, 3971-3982
Alexander Usyatinsky, Ph.D.XXXXXX YYYYYYYYyyyyy x. yyyyyy
6 Aavelord BlvdXxxxxxXxxxxxXxxxxx
Troy, NYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 12180xxxxxxxxxxxxxxxxxx0000 xxxxxx xxxx , xxxx , xxxxx
000000000 xxxxxx xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx , xxxx , xxxxx 00000
518-283-3506 xxx-xxx-xxxx
xxx-xxx-xxxx
518-331-6553 xxx-xxx-xxxx
xxx-xxx-xxxx
ausyatin@nyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxcap.rr.comabc@xyz.comabc@xyz.comabc@xyz.com
Country of Citizenship: United States
SSN: xxx-xx-xxxx
KSA
Ability to
analyze and interpret written materials, incxxxxxxluding technical materials, rules, regulations,
instructions, and reports.
Over the course of my extensive career in
Scientific Research, the ability to effectively analyze and interpret a wide range of scientific
data, technical materials, rules/regulations, instructions, and reports has
been vital to successfully steering varied research and
development projects. With the bulk of my U.S. career as a
Senior Research Scientist at Albanyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Molecular
Research Incxxxxxx./EnzyMed Incxxxxxx. (1995-2009), my extensive
involvement in collaborating with major pharmaceutical firms on crucial client
engagements as well as steering independent R&D
projects required ongoing analysis and interpretation of broad, complex written
materials throughout project scope.
Concxxxxxxurrent with my
earlier career as a Senior Research Associate in Russia, I held positions
specifically focused on the analysis and interpretation of scientific
materials. From 1982-1990 I was a part-time Document Analysis Specialist accountable for
analyzing journal paper and patent scientific information focused on wide areas of
chemistry. Within that time frame, 1988-1993, I was also a part-time Editor and
Reviewer with Organometallic
Chemistry in USSR, where I conducted thorough
review, proofreading and editing of papers submitted for publication.
Complementing this, I have published
over 40 papers in International and Russian journals as well as delivered
numerous presentations at International Conferencxxxxxxes, again
requiring extensive analysis and interpretation of complex written
materials. In earning several Patents, I relied heavily on
accurate interpretation and application of stringent regulatory
guidelines. Similarly, proficient analysis and
interpretation of scientific materials was vital in successfully developing,
completing and presenting my Ph.D. Thesis in carboranyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxl derivatives
of thallium.
REFEREXXXXXXNCES: Available upon request.
PERSONAL
US Citizen
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